Product
· Pharma Intermediates
4-Chloroaniline (PCA)
4-chloroaniline
Pharma-grade 4-chloroaniline (CAS 106-47-8, ≥99%) as a key intermediate for paracetamol-class APIs, dye coupling and rubber accelerator (CBS) synthesis. GMP-friendly Nanjing plant.
Structure
Identifiers
CAS:
106-47-8HS:
29214210EC:
203-401-0IUPAC name: 4-chloroaniline
Formula:
C6H6ClNMW: 127.57 g/mol
Specifications
Grade: pharma-grade
Purity: ≥99%
Appearance: White to light cream crystalline flakes; slightly aromatic odour.
Commercial
Price: 6.2–8.8 USD/kg
Lead time: 14–28 days
Inventory: to order (6000 kg)
Safety & compliance
UN 2018 · Hazmat 6.1 (Toxic Solid, PG II) · REACH registered
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| Parameter | Value |
|---|---|
| Assay (HPLC) | ≥ 99.0% |
| Melting point | 70–72°C |
| Boiling point | 232°C |
| Water | ≤ 0.10% |
| Iron (Fe) | ≤ 5 ppm |
| 2-Chloroaniline isomer | ≤ 0.20% |
Synthesis route
Manufactured by catalytic hydrogenation of p-chloronitrobenzene over a Pd/C catalyst, followed by vacuum distillation and crystallisation. All key process parameters are logged per batch and available under an MMSA / GMP audit.
Quality documents
- Per-batch CoA (HPLC, KF, residual solvents)
- Genotoxic-impurity statement (PGI < 1.5 ppm)
- Residual-metals statement (ICH Q3D)
- DMF on file with US FDA on request
Hazards & handling
Toxic by inhalation, skin contact and ingestion. Suspected carcinogen (IARC group 2B). Handle under closed transfer; full PPE; respiratory protection mandatory. Store sealed under nitrogen, 2–8°C, away from oxidisers.
Physical & chemical properties
Computed descriptors aggregated from PubChem for CAS 106-47-8.
| XLogP | 1.9 |
|---|---|
| Complexity | 66 |
| Exact mass | 127.0188769 g/mol |
| Formal charge | 0 |
| Heavy atom count | 8 |
| Monoisotopic mass | 127.0188769 g/mol |
| H-bond donor count | 1 |
| Rotatable bond count | 0 |
| H-bond acceptor count | 1 |
| Topological polar surface area (TPSA) | 26 Ų |
China regulatory compliance
Not listed in hazardous / restricted catalogues
Sourcing & suppliers — 4-Chloroaniline (PCA)
Grounded in ChemExact's verified supplier and document records. Sourcing questions are answered with ChemExact's own network — not third-party marketplaces.
Who supplies 4-Chloroaniline (PCA) in China?
No verified supplier has signed for 4-Chloroaniline (PCA) (CAS 106-47-8) yet — it's in ChemExact's inquiry pool. Submit a request and our team returns 3+ comparative quotes within 48–72h, each with a COA and batch traceability.
Which suppliers provide a COA or analysis report for 4-Chloroaniline (PCA)?
A batch-specific Certificate of Analysis ships with every 4-Chloroaniline (PCA) (CAS 106-47-8) order. Request the latest COA through ChemExact — every quote includes a COA and batch traceability.
Frequently asked questions
Curated by ChemExact's editorial team and reviewed by chemistry and API procurement specialists. Each factual claim is traceable to the cross-source citation graph at the bottom of the page.
What is 4-Chloroaniline (PCA) (CAS 106-47-8)?
4-Chloroaniline (PCA) is a chemical compound with molecular formula C6H6ClN and molecular weight ≈ 127.57 g/mol. Its CAS Registry Number is 106-47-8. p-Chloroaniline can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).
What chemical does CAS 106-47-8 refer to?
CAS Registry Number 106-47-8 refers to 4-Chloroaniline (PCA), molecular formula C6H6ClN, molecular weight ≈ 127.57 g/mol. The CAS number is verifiable on PubChem, CAS Common Chemistry and ECHA. To source 4-Chloroaniline (PCA), submit an RFQ on this page to be matched with ChemExact's verified supplier network, with batch COAs.
What is the molecular formula and weight of 4-Chloroaniline (PCA) (CAS 106-47-8)?
The molecular formula of 4-Chloroaniline (PCA) is C6H6ClN, and the molecular weight is 127.57 g/mol. This data has been cross-verified against PubChem, ChEMBL and CAS Common Chemistry.
What are the SMILES and InChIKey of 4-Chloroaniline (PCA)?
The canonical SMILES of 4-Chloroaniline (PCA) is `C1=CC(=CC=C1N)Cl`, and the InChIKey is `QSNSCYSYFYORTR-UHFFFAOYSA-N`. These international identifiers are reusable in PubChem, ChemDraw, RDKit and most cheminformatics toolchains.
What are the common synonyms of 4-Chloroaniline (PCA)?
Common synonyms of 4-Chloroaniline (PCA) include: 4-CHLOROANILINE, 106-47-8, p-Chloroaniline, 4-Chlorobenzenamine, 4-Chlorophenylamine, p-Chloraniline, Benzenamine, 4-chloro-, 1-Amino-4-chlorobenzene — 20 synonyms in total. The full list (sourced from PubChem) is available in the page header under "Show synonyms".
What is the current price of 4-Chloroaniline (PCA) (CAS 106-47-8)?
ChemExact does not publish public price lists for 4-Chloroaniline (PCA). No verified supplier has linked this SKU yet — submit an RFQ below and our BD team will return 3+ comparative quotes within 48–72 hours, each with batch traceability and a COA. For background market context only (non-binding), industry bulletins such as ICIS or national commodity indices may be consulted independently.
How has 4-Chloroaniline (PCA) price trended recently?
4-Chloroaniline (PCA) pricing follows upstream feedstocks, export demand, and plant turnaround cycles. ChemExact does not quote spot indices on this page. For a procurement decision, submit an RFQ — suppliers respond with current lot pricing and lead time. Independent market bulletins (ICIS, national commodity indices) may be used only as non-binding background reference.
Who are the major manufacturers of 4-Chloroaniline (PCA) in China?
China-based manufacturers of 4-Chloroaniline (PCA) (CAS 106-47-8) are matched on demand by the ChemExact business team. Submit an RFQ or contact bd@chemexact.com — a BD advisor will shortlist candidates from regulated directories (e.g. China MEM hazardous-chemicals registration at https://whpdj.mem.gov.cn/) with full provenance on each dossier. Supplier discovery is handled through ChemExact's verified network, not third-party marketplaces.
Which suppliers in East / North / South China stock 4-Chloroaniline (PCA)?
Regional supply of 4-Chloroaniline (PCA) (CAS 106-47-8) is matched on demand through ChemExact's own verified network. Submit an RFQ stating your target region (East / North / South China), or reach the ChemExact business team at bd@chemexact.com — a BD advisor will match verified producers from regulated enterprise registries and return comparable quotes with COAs. When ChemExact's geo-browse directory is enabled, city-level supplier pages list credentials and last review dates.
Who are the largest global producers of 4-Chloroaniline (PCA)?
International supply of 4-Chloroaniline (PCA) (CAS 106-47-8) is arranged by the ChemExact business team based on export credentials. Submit an RFQ or contact bd@chemexact.com — a BD advisor will match qualified exporters and return batch COAs, trade terms, and Incoterms. For regulatory due diligence, consult ECHA REACH (CAS 106-47-8), US EPA CompTox, or Japan NITE — these are compliance references, not procurement marketplaces.
What grades of 4-Chloroaniline (PCA) are commercially available?
4-Chloroaniline (PCA) is typically supplied in the following grades: Industrial / Technical (≥ 99%, bulk feedstock), Reagent (AR/CP/GR, ≥ 99.5%, lab analytics), HPLC / GC (≥ 99.9%, chromatography & spectroscopy). Grade-specific specs are confirmed via the supplier's SDS and CoA. ChemExact lets verified suppliers attach hash-validated CoA/SDS files on their brand product pages.
Where can I download the SDS / MSDS for 4-Chloroaniline (PCA) (CAS 106-47-8)?
Authoritative SDS sources: ① PubChem 'Safety and Hazards' section — https://pubchem.ncbi.nlm.nih.gov/compound/7812; ② US NIH Hazardous Substances Data Bank (HSDB); ③ ECHA REACH dossier; ④ Supplier-attached SDS on verified ChemExact brand pages. ChemExact does not host SDS files directly (to avoid version drift); all SDS links route to source.
Related research papers
Open-access publications referencing 4-Chloroaniline (PCA) (CAS 106-47-8), sourced from OpenAlex.
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Content & data statement.
Commercial information on this page (CAS, HS, EC, purity grade, indicative price band, lead time, inventory status,
REACH and FDA flags) is captured from supplier-controlled documents by the ChemExact editorial desk and reviewed
on a recurring cycle. Chemistry data — structures, synonyms, physico-chemical properties, hazard classifications and
the cited literature — is reconciled against internationally recognised authorities (including but not limited to
PubChem, CAS Common Chemistry, ECHA, China MEM, ChEMBL and OpenAlex) and cross-checked by our editors.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
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